Cain Velasquez @ UFC 146

This fight is said to be the biggest this year.

UFC 146's lineup is getting bigger and bigger – both literally and figuratively.

Former UFC heavyweight champions Cain Velasquez (9-1 MMA, 7-1 UFC) and Frank Mir (16-5 MMA, 14-5 UFC) will meet at the May event.

The winner gets a guaranteed title shot against either champion Junior Dos Santos or Alistair Overeem, who meet in the same night's headliner.

UFC 146, which also includes heavyweights Roy Nelson vs. Antonio Silva, takes place May 26 at Las Vegas' MGM Grand Garden Arena. The main card airs on pay-per-view while FX carries the prelims.

Velasquez vs. Mir is expected to take the co-headlining slot.

Velasquez fights for the first time since November, when he lost his belt to Dos Santos in a 64-second UFC on FOX 1 headliner. Prior to that, the former NCAA Division I All-American wrestler opened his career with a 9-0 mark that included eight knockouts. He won his belt with a TKO of Brock Lesnar, but after a yearlong layoff due to an injured shoulder, he lost it to Dos Santos in his next bout.

Unlike most UFC fights, officials haven't booked a recent loser against another recent loser. In fact, Mir recently has continued a career resurgence with a three-fight win streak over Mirko "Cro Cop" Filipovic (KO), Nelson (decision) and Antonio Rodrigo Nogueira (a come-from-behind submission). In fact, his only losses in his past nine fights have come in title fights to Lesnar and Shane Carwin.

The latest UFC 146 card now includes:

    Champ Junior Dos Santos vs. Alistair Overeem (for heavyweight title)
    Frank Mir vs. Cain Velasquez
    Edson Barboza vs. Evan Dunham
    Roy Nelson vs. Antonio Silva
    Dan Hardy vs. Duane "Bang" Ludwig
    Diego Brandao vs. Darren Elkins
    C.B. Dollaway vs. Jason "Mayhem" Miller
    Shane Del Rosario vs. Gabriel Gonzaga
    Kyle Kingsbury vs. Glover Teixeira
    Paul Sass vs. Jacob Volkmann

More fight information:

To be frank, there's never been a better time to lay down some cheddar on Mir.

That's because the former UFC Heavyweight Champion, who's been on a long and arduous journey in pursuit of the 265-pound crown, is a +325 underdog in his fight against Cain Velasquez, booked for UFC 146 on May 26, 2012, at the MGM Grand Garden Arena in Las Vegas, Nevada.

Velasquez is the -500 favorite, according to our fiscal friends at Best Fight Odds.

Despite a three-fight winning streak, one that culminated in a bone-breaking win over Antonio Rodrigo Nogueira at UFC 140 last December, Mir (16-5) was lit up on his feet by the aging Brazilian prior to the submission finish. Velasquez, widely-recognized as the division's finest wrestler, also has knockout power and never-ending cardio.

But -500?

Once considered unstoppable, "Brown Pride" was brown-bagged and eaten for lunch by a hungry Brazilian bomb-dropper named Junior dos Santos, whose two shots to the dome ended their UFC on FOX headliner in just over a minute.

The poor performance by Velasquez (9-1), which may have been overly-criticized considering he only had 64 seconds to strut his stuff, was attributed to his long layoff for shoulder surgery, as well as a bum knee sustained in training camp.

But was the loss to "Cigano" a bump in the road? Or the beginning of the end?

We know what the oddsmakers think. How about you? Let's get some initial reactions to the opening lines. Cain getting too much respect? Or Frank not getting enough?